FABP5 Inhibitor Program for Breast and Prostate Cancers

Scientific and Clinical Validation

  • Fatty Acid Binding Protein 5 (FABP5) Inhibitor with high potency and selectivity
  • FABP5 is an intracellular protein that chaperones lipids including endocannabinoids and fatty acids
  • In vivo efficacy in models of pain, anxiety, and inflammation through mechanisms involving the endocannabinoid system
  • In vivo efficacy in animal models of prostate cancer through mechanisms involving the regulation of pro-tumoral and pro-metastatic proteins
  • FABP5 is a validated target in breast, prostate and cervical cancers, and is implicated in many other cancer types

Learn more about ART26.12

Formulation and Intellectual Property

  • Three patents issued
  • 14 patent applications pending, with two additional planned


  • Prostate cancer
  • Breast cancer
  • Other cancers
  • Pain/Inflammation
  • Anxiety/PTSD

What is FABP5?

Fatty acid binding proteins (FABPs) are proteins within a cell that help to transport lipophilic (fat loving), hydrophobic (water fearing) molecules around intracellular compartments.  There are several different types of FABPs, and FABP5 is one of the main transport mechanisms for endocannabinoids, fatty acids and their derivatives. Fatty acids like anandamide (AEA) are bound within the center of the FABP molecule, which acts like a barrel around the fatty acid molecule.


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  9. Source: AstraZeneca, adMare. Data on file
  10. FABP5 protein structure image by Emw – Own work, CC BY-SA 3.0