Benzimidazole Derivative for Cancer Anorexia Cachexia Syndrome (CACS)

Scientific and Clinical Validation

  • Dual CB1/CB2 receptor potent full agonist (learn more about CB1/CB2)
  • Phase 1 study in subjects with lower back pain that were otherwise healthy demonstrated statistically significant increase in body weight versus drug exposure
  • Phase 1b study completed
  • Phase 2a study enrolling (CAReS Trial)

Learn more about our Cancer Appetite Recovery Study (CAReS) in cancer anorexia


Formulation and Intellectual Property

  • Formulated as once daily oral capsules
  • Two patents issued and one pending application
  • New Chemical Entity structurally distinct from the phytocannabinoids i.e. THC
  • Peripherally selective (targets receptors in the body, not the brain)

Cancer Anorexia: The Unmet Need



  • Cancer Anorexia and Cachexia Syndrome (CACS) affects greater than 60% of advanced stage cancer patients
  • CACS: No regulatory authorized medicine (no current FDA, MHRA or EMA approved therapies exist for CACS)
  • 2020 ASCO Guidelines recommend no specific pharmacological intervention as standard of care
  • Potential future applications in anorexia beyond cancer

The CAReS Trial

Currently, ART27.13 is the focus of a phase 1b/2a, randomized, placebo-controlled trial called the Cancer Appetite Recovery Study (CAReS Trial). The CAReS Trial aims to determine a safe and effective dose as well as activity of ART27.13 in terms of lean body mass, weight gain, and improvement of anorexia. CAReS is currently enrolling patients at numerous sites.


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  2. Data from Market Intel Reports 2016 as quoted in Innovus Pharma to Enter the Oncology Supportive Care Market With an Exclusive License to Two GRAS-Listed OTC Compounds for Cachexia and Muscle Growth and Repair From the University of Iowa Research Foundation. Innovus Press Release June 6, 2017, ex-US estimate based upon market forecast model from US sales figures;
  3. Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials. Advani, Shailesh M et al., BMC cancer vol. 18,1 1174. 27 Nov. 2018, doi:10.1186/s12885-018-5080-4;
  4. Sánchez‐Lara K, Ugalde‐Morales E, Motola‐Kuba D, Green D. Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy. Br J Nutr 2013;109:894‐7,
  5. Management of Cancer Cachexia: ASCO Guideline, May 2020;
  6. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD004310.
  9. Source: AstraZeneca, adMare. Data on file